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Broadly, I am interested in the interplay between psychological-level phenomena and neurobiological mechanisms as they relate to disturbances of perception, belief, motivation, and emotional processing in people with mental illness, principally schizophrenia and bipolar disorder. I pursue these themes in a variety of contexts, including longitudinal studies of at risk populations and patients in various phases of illness and studies of twin pairs concordant and discordant for these illness phenotypes. I am particularly interested in understanding the mechanisms underlying the emergence of psychosis during adolescence and early adulthood and developing effective intervention and prevention strategies targeting these mechanisms. Our approaches include structural, functional, metabolic, and neurochemical brain imaging, neurocognitive assessment, and quantitative and molecular genetics.