Our laboratory investigates the cellular and network mechanisms of cortical function using a variety of in vitro and in vivo approaches, from patch clamp recording in vivo, to voltage sensitive dye imaging and two photon microscopy in vitro. Recently, we have discovered that intracortical synaptic communication operates through both an analog and digital mode. We are currently investigating the mechanisms by which axons and synapses may operate in this regime.
Additional topics we are investigating are Recurrent Networks and their potential contribution to Gain Modulation, Working Memory, and Attention. In addition, we examine Visual Cortical receptive field mechanisms and fast plasticity. Finally, we also are investigating the mechanisms of cortical dynamics in the vibrissal and auditory systems of the awake animal. Together, our studies span from the sub-cellular, through the cellular and local network, all the way to the awake behaving animal in an effort to understand the cellular and network mechanisms of cortical function and dysfunction.
Specialized Terms: Cellular mechanisms of cortical function; Thalamocortical function and modulation