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The research focus of my laboratory is on the genetics of brain structure and function. Our goals include elucidation of the neurobiological roots of major mental illnesses through the integration of cognitive neuropsychological, functional and structural neuroimaging, and behavioral and molecular genetic approaches. The ultimate goals of this research is the identification of genes involved in affective and psychotic illnesses as well as genes that influence non-pathological brain structure and function. Localization of genes involved in mental illness should significantly contribute to an understanding of the underlying biology of these complex diseases, which in turn should improve future treatments and create the potential for prevention strategies.