Research in the lab is focused on characterizing age differences and individual differences across adulthood in the motivational and cognitive processes that support decision making. Our approach combines several disciplines including psychology, behavioral economics/finance, neuroscience, and public health. We use a variety of methods including behavioral studies, experience sampling in everyday life, structural and functional MRI, and PET receptor imaging. The goal of our translational research program is to make contributions to basic science (e.g., more precisely characterizing brain aging) and to translate our findings for improving public health and well being.
Samanez-Larkin, G.R., Worthy, D.A., Mata, R., McClure, S.M., Knutson, B (2014) Adult age differences in frontostriatal representation of prediction error but not reward outcome. Cognitive Affective and Behavioral Neuroscience, 14 (2), 672–682.
Samanez-Larkin, G.R., Buckholtz, J.W., Cowan, R.L., Woodward, N.D., Li, R., Ansari, M.S., Arrington, C.M., Baldwin, R.M., Smith, C.E., Treadway, M.T., Kessler, R.M., Zald, D.H. (2013) A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility. Biological Psychiatry, 74(2), 99–105.
Samanez-Larkin, G.R., Levens, S.M., Perry, L.M., Dougherty, R.F., Knutson, B. (2012) Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning. Journal of Neuroscience, 32(15), 5333–5337.
Samanez-Larkin, G.R., Kuhnen, C.M., Yoo, D.J., Knutson, B. (2010) Variability in nucleus accumbens activity mediates age-related suboptimal financial risk taking. Journal of Neuroscience, 30(4), 1426–1434.
Samanez-Larkin, G.R., Hollon, N.G., Carstensen, L.L., Knutson, B. (2008) Individual differences in insular sensitivity during loss anticipation predict avoidance learning. Psychological Science, 19(4), 320–323.